Acute kidney injury or AKI is a condition resulting in a rapid inflammation and loss of kidney function necessitating highly specialised medical care and presenting with a high mortality. Survivors from AKI are at high risk for chronic kidney disease, increased morbidity and a greatly reduced quality of life.
40-60% of critical care admissions
3 million patients in Europe and the US
700,000 deaths annually
There are many different causes to AKI: sepsis, cardiovascular surgery, rhabdomyolysis, organ transplantation, cancer treatments, exposure to nephrotoxic drugs or trauma are among the most common.
Free iron, which mainly comes from hemolysis, is a strong promoter of AKI by catalyzing the Fenton Haber-Weiss reactions it leads to the production of free radicals which in turn create oxidative stress, vascular injuries, apoptosis and ferroptosis.
More than $10 billion are spent each year to manage AKI
MexBrain has developed a technology that combines an ultrachelating biopolymer and a dialysis device to specifically extract free iron from patients. Learn more about the science behind MexBrain’s technology: